Interactions and Contraindications of Hydroxychloroquine with Other Medications


Hydroxychloroquine is a medication commonly used to treat certain types of malaria as well as autoimmune conditions such as rheumatoid arthritis and lupus. In recent times, it has gained significant attention as a potential treatment for COVID-19. However, like any other medication, hydroxychloroquine can interact with other drugs, potentially causing harmful effects or reducing its effectiveness. It is crucial to be aware of these interactions and contraindications to ensure safe and effective treatment.

Interactions and Contraindications of Hydroxychloroquine with Other Medications 2

1. Drug Interactions

Hydroxychloroquine can interact with several other medications, either enhancing or reducing their effects. Some notable drug interactions include:

  • Antacids: Taking hydroxychloroquine with antacids containing aluminum or magnesium can reduce its absorption and effectiveness. It is recommended to separate the administration of these medications by at least four hours.
  • Digoxin: Concurrent use of hydroxychloroquine and digoxin, a medication used to treat heart conditions, can increase the risk of digoxin toxicity.
  • Antiepileptic Drugs: Hydroxychloroquine can reduce blood levels of certain antiepileptic drugs such as phenytoin and valproic acid, potentially leading to a reduced effect. Dose adjustments may be necessary.
  • It is essential to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, to minimize the risk of drug interactions.

    2. Contraindications

    While hydroxychloroquine is generally well-tolerated, there are certain contraindications that should be considered before initiating treatment:

  • Allergy: Individuals who have a known allergy or hypersensitivity to hydroxychloroquine or other related medications should avoid its use. Allergic reactions can range from mild skin rashes to severe anaphylaxis.
  • Retinal or Visual Field Changes: Hydroxychloroquine has the potential to cause retinal or visual field changes, especially with long-term use or higher doses. Regular monitoring of visual function is recommended, and treatment should be discontinued if any visual abnormalities are observed.
  • Heart Conditions: Individuals with pre-existing heart conditions or an abnormal heart rhythm should exercise caution when taking hydroxychloroquine. This medication can prolong the QT interval, increasing the risk of life-threatening arrhythmias.
  • 3. Monitoring and Precautions

    Close monitoring is essential while taking hydroxychloroquine, especially in individuals with certain risk factors or comorbidities. Some key considerations include:

  • Ophthalmologic Monitoring: Regular eye examinations, including tests for visual acuity, retinal function, and visual fields, should be conducted to detect any retinal or visual changes. This is particularly important for individuals taking hydroxychloroquine long-term or at higher doses.
  • Cardiac Monitoring: Electrocardiography (ECG) should be performed periodically, especially in individuals with underlying heart conditions. Any significant prolongation of the QT interval should be closely evaluated by a cardiologist.
  • Renal and Hepatic Function: Hydroxychloroquine is primarily excreted by the kidneys and can accumulate in individuals with impaired renal function. Regular renal and hepatic function tests are important to ensure appropriate dosing and detect any potential toxicities.
  • It is crucial to follow your healthcare provider’s instructions, attend all scheduled appointments, and promptly report any new or worsening symptoms while taking hydroxychloroquine. We’re always working to provide a complete educational experience. For this reason, we suggest this external source containing supplementary details on the topic. Click for more information, immerse yourself further in the subject!


    Hydroxychloroquine is a valuable medication used in the management of various conditions. However, it is essential to be aware of its potential interactions with other drugs and the contraindications to ensure safe and effective treatment. Regular monitoring and adherence to recommended precautions can minimize the risks and maximize the benefits of hydroxychloroquine therapy.

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